1.
Indian J Biochem Biophys
;
1996 Jun; 33(3): 234-6
Article
in English
| IMSEAR
| ID: sea-29091
2.
Indian J Biochem Biophys
;
1990 Aug; 27(4): 228-39
Article
in English
| IMSEAR
| ID: sea-28437
ABSTRACT
Mode of action of some intercalators has been theoretically investigated on the basis of quantum mechanical perturbation method. Energies of H-bond interaction between drug chromophore and base pairs have been calculated in all possible orientations. The stacking energy has also been calculated with the base pairs. The effect of these interactions on specific recognition has also been discussed. On the basis of these studies, a model for the interaction of these drugs has been proposed. This explains the relative activities of acridine intercalators and satisfies the experimental observations.